Ontology highlight
ABSTRACT:
SUBMITTER: Moiseeva T
PROVIDER: S-EPMC5680267 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Moiseeva Tatiana T Hood Brian B Schamus Sandy S O'Connor Mark J MJ Conrads Thomas P TP Bakkenist Christopher J CJ
Nature communications 20171109 1
ATR kinase activity slows replication forks and prevents origin firing in damaged cells. Here we describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells. ATR-Chk1 inhibitor-induced origin firing is mediated by Cdc7 kinase through previously undescribed phosphorylations on GINS that induce an association between GINS and And-1. ATR-Chk1 inhibitor-induced origin firing is blocked by prior exposure to DNA damagin ...[more]