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Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy.

ABSTRACT: Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly expressed in diabetic nephropathy (DN) may be involved in the generation of DN-associated peptides in urine. We compared urinary peptide profiles of DN patients (macroalbuminuric, n?=?121) to diabetic patients with no evidence of DN (normoalbuminuric, n?=?118). 302 sequenced, differentially expressed peptides (adjusted p-value?

SUBMITTER: Krochmal M

PROVIDER: S-EPMC5680307 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy.

Krochmal Magdalena M Kontostathi Georgia G Magalhães Pedro P Makridakis Manousos M Klein Julie J Husi Holger H Leierer Johannes J Mayer Gert G Bascands Jean-Loup JL Denis Colette C Zoidakis Jerome J Zürbig Petra P Delles Christian C Schanstra Joost P JP Mischak Harald H Vlahou Antonia A

Scientific reports 20171109 1

Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly expressed in diabetic nephropathy (DN) may be involved in the generation of DN-associated peptides in urine. We compared urinary peptide profiles of DN patients (macroalbuminuric, n = 121) to diabetic patients with no evidence of DN (normoalbuminuric, ...[more]

PMID: 29123184

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