Ontology highlight
ABSTRACT:
SUBMITTER: Krochmal M
PROVIDER: S-EPMC5680307 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Krochmal Magdalena M Kontostathi Georgia G Magalhães Pedro P Makridakis Manousos M Klein Julie J Husi Holger H Leierer Johannes J Mayer Gert G Bascands Jean-Loup JL Denis Colette C Zoidakis Jerome J Zürbig Petra P Delles Christian C Schanstra Joost P JP Mischak Harald H Vlahou Antonia A
Scientific reports 20171109 1
Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly expressed in diabetic nephropathy (DN) may be involved in the generation of DN-associated peptides in urine. We compared urinary peptide profiles of DN patients (macroalbuminuric, n = 121) to diabetic patients with no evidence of DN (normoalbuminuric, ...[more]