Dataset Information

Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study.

ABSTRACT:

Background

It has long been proposed that albumin, bilirubin and uric acid may inhibit cancer development due to their anti-oxidative properties. However, there is a lack of population-based studies on blood levels of these molecules and cancer risk.

Methods

Associations between pre-diagnostic serum albumin, bilirubin and uric acid and the risks of common cancers as well as cancer death in the EPIC-Heidelberg cohort were evaluated by multivariable Cox regression analyses. A case-cohort sample including a random subcohort (n=2739) and all incident cases of breast (n=627), prostate (n=554), colorectal (n=256), and lung cancer (n=195) as well as cancer death (n=761) that occurred between baseline (1994-1998) and 2009 was used.

Results

Albumin levels were inversely associated with breast cancer risk (hazard ratio_{Quartile 4 vs Quartile 1} (95% CI): 0.71 (0.51, 0.99), P_{linear trend}=0.004) and overall cancer mortality (HR_{Q4 vs Q1} (95% CI): 0.64 (0.48, 0.86), P_{linear trend}<0.001) after multivariable adjustment. Uric acid levels were also inversely associated with breast cancer risk (HR_{Q4 vs Q1} (95% CI): 0.72 (0.53, 0.99), P_{linear trend}=0.043) and cancer mortality (HR_{Q4 vs Q1} (95% CI): 0.75 (0.58, 0.98), P_{linear trend}=0.09). There were no significant associations between albumin or uric acid and prostate, lung and colorectal cancer. Serum bilirubin was not associated with any cancer end point.

Conclusions

The present findings indicate that higher levels of albumin and uric acid are related to lower risks of breast cancer and cancer mortality. Further studies are needed to assess whether the observed associations are causal.

SUBMITTER: Kuhn T

PROVIDER: S-EPMC5680462 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study.

Kühn Tilman T Sookthai Disorn D Graf Mirja E ME Schübel Ruth R Freisling Heinz H Johnson Theron T Katzke Verena V Kaaks Rudolf R

British journal of cancer 20170912 10

<h4>Background</h4>It has long been proposed that albumin, bilirubin and uric acid may inhibit cancer development due to their anti-oxidative properties. However, there is a lack of population-based studies on blood levels of these molecules and cancer risk.<h4>Methods</h4>Associations between pre-diagnostic serum albumin, bilirubin and uric acid and the risks of common cancers as well as cancer death in the EPIC-Heidelberg cohort were evaluated by multivariable Cox regression analyses. A case-c ...[more]

PMID: 28898231

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Project description:IntroductionWhile the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage.Patients and methodsIncidence of intracerebral haemorrhage was studied among 28,416 individuals from the population-based Malmö Diet and Cancer cohort. Intracerebral haemorrhage cases were ascertained using the Swedish Hospital Discharge Register and the Stroke Register of Malmö, validated by review of hospital records and images, and classified by location by a neuroradiologist. Multivariable Cox regression was used.ResultsThree hundred and thirty-three intracerebral haemorrhages occurred, mean follow-up time was 18.4 years. Systolic blood pressure (hazard ratio per 10 mmHg 1.19 [95% confidence interval 1.13-1.26], diastolic blood pressure (hazard ratio 1.42 [1.27-1.59]), oral anticoagulants (hazard ratio 4.26 [2.17-8.38]), smoking (hazard ratio 1.45 [1.14-1.87]), living alone (hazard ratio 1.32 [1.04-1.69]) and low apolipoprotein B (hazard ratio per 10 mg/dL: 0.94 [0.90-0.99]) were significantly associated with incident intracerebral haemorrhage after multivariable adjustment. Systolic blood pressure, smoking and oral anticoagulants were associated with lobar intracerebral haemorrhage. Systolic blood pressure, diastolic blood pressure, living alone and diabetes were associated with non-lobar intracerebral haemorrhage. Diabetes and diastolic blood pressure showed significantly different relationships with lobar and non-lobar intracerebral haemorrhage. Alcohol, apolipoprotein A1, body mass index, waist circumference, physical activity and education were not independently associated with intracerebral haemorrhage.Discussion and conclusions: Blood pressure, smoking, low apolipoprotein B, oral anticoagulants and living alone were associated with intracerebral haemorrhage. Diabetes was associated with non-lobar intracerebral haemorrhage only. Further research is required on differences between lobar and non-lobar intracerebral haemorrhage.

Dataset Information

Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study.

Background

Methods

Results

Conclusions

Publications

Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study.

Similar Datasets

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