Clonal chromosomal abnormalities appearing in Philadelphia chromosome-negative metaphases during CML treatment.

ABSTRACT: Clonal chromosomal abnormalities in Philadelphia chromosome-negative (CCA/Ph^-) metaphases emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated with tyrosine kinase inhibitors (TKIs). We assessed the characteristics and prognostic impact of 598 patients with CP-CML treated on clinical trials with various TKIs. CCA/Ph^- occurred in 58 patients (10%); the most common were -Y in 25 (43%) and trisomy 8 in 7 patients (12%). Response to TKI therapy was similar for patients with CCA/Ph^- and those without additional chromosomal abnormalities (ACAs). We further categorized CCA/Ph^- into those in which -Y was the only clonal abnormality, and all others. We found that patients with non -Y CCA/Ph^- had worse failure-free

SUBMITTER: Issa GC 

PROVIDER: S-EPMC5680612 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature