Ontology highlight
ABSTRACT:
SUBMITTER: Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu
PROVIDER: S-EPMC5680778 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell 20170601 7
Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including LZTR1, EEF1A1, SF3B1, and SMARCA4. Significant alterations by mutation or downregulation by hypermethylati ...[more]