Ontology highlight
ABSTRACT:
SUBMITTER: Dahlmans D
PROVIDER: S-EPMC5681243 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Dahlmans Dennis D Houzelle Alexandre A Andreux Pénélope P Jörgensen Johanna A JA Wang Xu X de Windt Leon J LJ Schrauwen Patrick P Auwerx Johan J Hoeks Joris J
Molecular metabolism 20170831 11
<h4>Objective</h4>Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are limited. Therefore, the present study aimed to identify novel microRNAs regulating skeletal muscle mitochondrial metabolism.<h4>Methods and results</h4>We conducted an unbiased, hypothesis-free microRNA silencing screen in C2C12 myoblas ...[more]