Ontology highlight
ABSTRACT:
SUBMITTER: Burwitz BJ
PROVIDER: S-EPMC5681693 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Burwitz Benjamin J BJ Wu Helen L HL Abdulhaqq Shaheed S Shriver-Munsch Christine C Swanson Tonya T Legasse Alfred W AW Hammond Katherine B KB Junell Stephanie L SL Reed Jason S JS Bimber Benjamin N BN Greene Justin M JM Webb Gabriela M GM Northrup Mina M Laub Wolfram W Kievit Paul P MacAllister Rhonda R Axthelm Michael K MK Ducore Rebecca R Lewis Anne A Colgin Lois M A LMA Hobbs Theodore T Martin Lauren D LD Ferguson Betsy B Thomas Charles R CR Panoskaltsis-Mortari Angela A Meyers Gabrielle G Stanton Jeffrey J JJ Maziarz Richard T RT Sacha Jonah B JB
Nature communications 20171110 1
Allogeneic hematopoietic stem cell transplantation (HSCT) is a critically important therapy for hematological malignancies, inborn errors of metabolism, and immunodeficiency disorders, yet complications such as graft-vs.-host disease (GvHD) limit survival. Development of anti-GvHD therapies that do not adversely affect susceptibility to infection or graft-vs.-tumor immunity are hampered by the lack of a physiologically relevant, preclinical model of allogeneic HSCT. Here we show a spectrum of di ...[more]