Ontology highlight
ABSTRACT:
SUBMITTER: Mandal C
PROVIDER: S-EPMC5682251 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Mandal Chanchal C Kim Sun Hwa SH Kang Sung Chul SC Chai Jin Choul JC Lee Young Seek YS Jung Kyoung Hwa KH Chai Young Gyu YG
Molecules and cells 20171017 10
Histone-modifying enzymes are key players in the field of cellular differentiation. Here, we used GSK-J4 to profile important target genes that are responsible for neural differentiation. Embryoid bodies were treated with retinoic acid (10 μM) to induce neural differentiation in the presence or absence of GSK-J4. To profile GSKJ4-target genes, we performed RNA sequencing for both normal and demethylase-inhibited cells. A total of 47 and 58 genes were up- and down-regulated, respectively, after G ...[more]