Ontology highlight
ABSTRACT:
SUBMITTER: Weber ANR
PROVIDER: S-EPMC5682317 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in immunology 20171108
Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor signaling in the development and functioning of adaptive immunity. Growing evidence also suggests multiple roles for BTK in mononuclear cells of the innate immune system, especially in dendritic cells and macrophages. For example, BTK has been shown to function in Toll-like receptor-mediated recognition of infectious agents, cellular maturation and recruitment processes, and Fc receptor signaling. M ...[more]