Ontology highlight
ABSTRACT:
SUBMITTER: Charles KN
PROVIDER: S-EPMC5682597 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Charles Khanichi N KN Li Min-Dian MD Engin Feyza F Arruda Ana Paula AP Inouye Karen K Hotamisligil Gökhan S GS
Cell reports 20171001 2
Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a high-calorie diet impairs metabolism and accelerates aging; conversely, calorie restriction (CR) prevents age-related metabolic diseases and extends lifespan. However, it is unclear whether preservation of metabolic health is sufficient to extend lifespan. We utilized a genetic mouse model lacking Fabp4/5 that confers protection against metabolic diseases and shares molecu ...[more]