Ontology highlight
ABSTRACT:
SUBMITTER: Huang Z
PROVIDER: S-EPMC5682619 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Huang Zhenhua Z Li Heran H Zhang Qian Q Lu Fangzheng F Hong Mei M Zhang Zhigang Z Guo Xiaocui X Zhu Yuanju Y Li Sanming S Liu Hongzhuo H
ACS medicinal chemistry letters 20170930 11
Idiopathic pulmonary fibrosis (IPF) is a serious and deadly disease for which treatment options are limited. The recent approval of antifibrosis agent nintedanib represents one of the first therapeutic approaches for the treatment of IPF. Here, we report novel indolinone-based multikinase inhibitors that target angiogenesis and fibrosis pathways and may serve as potential therapeutics for IPF. KBP-7018 is a novel, tyrosine kinase-selective inhibitor with potent effects on three fibrotic kinases ...[more]