Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation.
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ABSTRACT:
SUBMITTER: Atarashi K
PROVIDER: S-EPMC5682622 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Ectopic colonization of oral bacteria in the intestine drives T<sub>H</sub>1 cell induction and inflammation.
Atarashi Koji K Suda Wataru W Luo Chengwei C Kawaguchi Takaaki T Motoo Iori I Narushima Seiko S Kiguchi Yuya Y Yasuma Keiko K Watanabe Eiichiro E Tanoue Takeshi T Thaiss Christoph A CA Sato Mayuko M Toyooka Kiminori K Said Heba S HS Yamagami Hirokazu H Rice Scott A SA Gevers Dirk D Johnson Ryan C RC Segre Julia A JA Chen Kong K Kolls Jay K JK Elinav Eran E Morita Hidetoshi H Xavier Ramnik J RJ Hattori Masahira M Honda Kenya K
Science (New York, N.Y.) 20171001 6361
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of <i>Klebsiella</i> spp. isolated from the salivary microbiota are strong inducers of T helper 1 (T<sub>H</sub>1) cells when they colonize in the gut. These <i>Klebsiella</i> strains are resistant to multip ...[more]
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