Elevated plasma levels of interleukin-16 in patients with acute myocardial infarction.

ABSTRACT: Interleukin (IL)-16, a polypeptide cytokine, plays a crucial role in the inflammatory process, acting as a chemoattractant for peripheral immune cells and has been linked to various inflammatory diseases. However, its role in patients with acute myocardial infarction (AMI) is unclear.We retrospectively analyzed serum levels of IL-16 in blood of patients with (STEMI, n?=?45) and without ST-segment elevation myocardial infarction (NSTEMI, n?=?42) compared with controls with excluded coronary artery disease (n?=?55). Furthermore, correlation analysis with inflammatory cells, C-reactive protein (CRP) levels, dendritic cell precursors (DCPs), and other clinical and biochemical markers was performed.Compared with controls, patients with STEMI and NSTEMI evidenced higher levels of IL-16 in pg/mL (STEMI: 759.38?±?471.54, NSTEMI: 677.77?±?438.8, control: 500.45?±?432.21; P?=?.002). IL-16 correlated with CRP (r?=?0.26, P?=?.001), leucocytes (r?=?0.38, P?

SUBMITTER: Schernthaner C 

PROVIDER: S-EPMC5682786 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature