Ontology highlight
ABSTRACT:
SUBMITTER: Huffaker TB
PROVIDER: S-EPMC5682963 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Huffaker Thomas B TB Lee Soh-Hyun SH Tang William W WW Wallace Jared A JA Alexander Margaret M Runtsch Marah C MC Larsen Dane K DK Thompson Jacob J Ramstead Andrew G AG Voth Warren P WP Hu Ruozhen R Round June L JL Williams Matthew A MA O'Connell Ryan M RM
The Journal of biological chemistry 20170914 45
MicroRNA-155 (miR-155) regulates antitumor immune responses. However, its specific functions within distinct immune cell types have not been delineated in conditional KO mouse models. In this study, we investigated the role of miR-155 specifically within T cells during the immune response to syngeneic tumors. We found that miR-155 expression within T cells is required to limit syngeneic tumor growth and promote IFNγ production by T cells within the tumor microenvironment. Consequently, we found ...[more]