Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC5683091 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Liu Fabao F Ma Fengfei F Wang Yuyuan Y Hao Ling L Zeng Hao H Jia Chenxi C Wang Yidan Y Liu Peng P Ong Irene M IM Li Baobin B Chen Guojun G Jiang Jiaoyang J Gong Shaoqin S Li Lingjun L Xu Wei W
Nature cell biology 20171023 11
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of metabolism from oxidative phosphorylation to aerobic glycolysis in breast cancer cells. Oxidative phosphorylation depends on mitochondrial calcium concentration, which becomes critical for cancer cell su ...[more]