Translation elicits a growth rate-dependent, genome-wide, differential protein production in Bacillus subtilis.

ABSTRACT: Complex regulatory programs control cell adaptation to environmental changes by setting condition-specific proteomes. In balanced growth, bacterial protein abundances depend on the dilution rate, transcript abundances and transcript-specific translation efficiencies. We revisited the current theory claiming the invariance of bacterial translation efficiency. By integrating genome-wide transcriptome datasets and datasets from a library of synthetic gfp-reporter fusions, we demonstrated that translation efficiencies in Bacillus subtilis decreased up to fourfold from slow to fast growth. The translation initiation regions elicited a growth rate-dependent, differential production of proteins without regulators, hence revealing a unique, hard-coded, growth rate-dependent mode of regulation. We

SUBMITTER: Borkowski O 

PROVIDER: S-EPMC5683663 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature