Ontology highlight
ABSTRACT:
SUBMITTER: Hakeda-Suzuki S
PROVIDER: S-EPMC5683756 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Hakeda-Suzuki Satoko S Takechi Hiroki H Kawamura Hinata H Suzuki Takashi T
eLife 20171108
Formation of a functional neuronal network requires not only precise target recognition, but also stabilization of axonal contacts within their appropriate synaptic layers. Little is known about the molecular mechanisms underlying the stabilization of axonal connections after reaching their specifically targeted layers. Here, we show that two receptor protein tyrosine phosphatases (RPTPs), LAR and Ptp69D, act redundantly in photoreceptor afferents to stabilize axonal connections to the specific ...[more]