Ontology highlight
ABSTRACT:
SUBMITTER: Wenzel SE
PROVIDER: S-EPMC5683852 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wenzel Sally E SE Tyurina Yulia Y YY Zhao Jinming J St Croix Claudette M CM Dar Haider H HH Mao Gaowei G Tyurin Vladimir A VA Anthonymuthu Tamil S TS Kapralov Alexandr A AA Amoscato Andrew A AA Mikulska-Ruminska Karolina K Shrivastava Indira H IH Kenny Elizabeth M EM Yang Qin Q Rosenbaum Joel C JC Sparvero Louis J LJ Emlet David R DR Wen Xiaoyan X Minami Yoshinori Y Qu Feng F Watkins Simon C SC Holman Theodore R TR VanDemark Andrew P AP Kellum John A JA Bahar Ivet I Bayır Hülya H Kagan Valerian E VE
Cell 20171001 3
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty acids as substrates. Mechanisms of the altered 15-LO substrate specificity are enigmatic. We sought a common ferroptosis regulator for 15LO. We discovered that PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 1 ...[more]