Ontology highlight
ABSTRACT:
SUBMITTER: Baker MR
PROVIDER: S-EPMC5683905 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Current opinion in structural biology 20170612
Inositol 1,4,5-trisphosphate receptors (IP<sub>3</sub>Rs) are ubiquitously expressed intracellular Ca<sup>2+</sup> channels and the major mediators of cellular Ca<sup>2+</sup> signals generated by the release of Ca<sup>2+</sup> ions from intracellular stores in response to a variety of extracellular stimuli. Despite established physiological significance and proven involvements of IP<sub>3</sub>R channels in many human diseases, detailed structural basis for signal detection by these ion channel ...[more]