Ontology highlight
ABSTRACT:
SUBMITTER: Zhu B
PROVIDER: S-EPMC5684335 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhu Bing B Jiang LuLin L Huang Timothy T Zhao Yingjun Y Liu Tongfei T Zhong Yongwang Y Li Xiaoguang X Campos Alexandre A Pomeroy Kenneth K Masliah Eliezer E Zhang Dongxian D Xu Huaxi H
Nature communications 20171113 1
Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the ERAD complex and its role in neurodegeneration are not yet fully understood. Here, using proteomic and FRET analyses, we demonstrate that the ER protein membralin is an ERAD component, which mediates degradation of ER luminal and membrane substrates. Interestingly, we identify nicastrin, a key component of the γ-secretase complex, as a membra ...[more]