Ontology highlight
ABSTRACT:
SUBMITTER: Das S
PROVIDER: S-EPMC5684340 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Das Sadhan S Senapati Parijat P Chen Zhuo Z Reddy Marpadga A MA Ganguly Rituparna R Lanting Linda L Mandi Varun V Bansal Anita A Leung Amy A Zhang Selena S Jia Ye Y Wu Xiwei X Schones Dustin E DE Natarajan Rama R
Nature communications 20171113 1
Angiotensin II (AngII) promotes hypertension and atherosclerosis by activating growth-promoting and pro-inflammatory gene expression in vascular smooth muscle cells (VSMCs). Enhancers and super-enhancers (SEs) play critical roles in driving disease-associated gene expression. However, enhancers/SEs mediating VSMC dysfunction remain uncharacterized. Here, we show that AngII alters vascular enhancer and SE repertoires in cultured VSMCs in vitro, ex vivo, and in AngII-infused mice aortas in vivo. A ...[more]