Ontology highlight
ABSTRACT:
SUBMITTER: Khan SH
PROVIDER: S-EPMC5684351 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20171113 1
Intrinsically disordered (ID) regions of the transcription factor proteins have much larger frequency of phosphorylation sites than ordered regions, suggesting an important role in their regulatory capacity. Consistent with this phenomenon, most of the functionally known phosphorylation sites in the steroid receptor family of transcription factors are located in the ID N-terminal domain that contains a powerful activation function (AF1) region. In this study, we determined the structural and fun ...[more]