Ontology highlight
ABSTRACT:
SUBMITTER: Yamada S
PROVIDER: S-EPMC5684480 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Yamada Sohsuke S Kawaguchi Hiroaki H Yamada Tomonobu T Guo Xin X Matsuo Kei K Hamada Taiji T Miura Naoki N Tasaki Takashi T Tanimoto Akihide A
Journal of atherosclerosis and thrombosis 20170511 11
<h4>Aim</h4>We have recently established a novel swine model for studies of atherosclerosis using Microminipigs<sup>TM</sup> (µMPs) fed a high-fat/high-cholesterol diet (HcD). Using this swine model, we re-evaluated the effects of dietary cholic acid (CA) on serum lipid profile, atherosclerosis and hepatic injuries.<h4>Methods</h4>The µMPs were fed HcD supplemented with 0.7% CA (HcD+CA) for eight weeks, and the effect of CA on serum lipoprotein levels, expression of oxidative stress markers, adi ...[more]