Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats.
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ABSTRACT:
SUBMITTER: Padilla J
PROVIDER: S-EPMC5685263 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats.
Padilla Jaume J Thorne Pamela K PK Martin Jeffrey S JS Rector R Scott RS Akter Sadia S Davis J Wade JW Laughlin M Harold MH Jenkins Nathan T NT
Experimental biology and medicine (Maywood, N.J.) 20170123 6
We examined the effects of metformin, a commonly used antidiabetic drug, on gene expression in multiple arteries. Specifically, transcriptional profiles of feed arteries and second branch order arterioles in the soleus, gastrocnemius, and diaphragm muscles as well as aortic endothelial scrapes were examined from obese insulin-resistant Otsuka Long-Evans Tokushima Fatty rats treated with ( n = 9) or without ( n = 10) metformin from 20 to 32 weeks of age. Metformin-treated rats exhibited a reducti ...[more]
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