Dataset Information

Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012.

ABSTRACT: Cadmium (Cd) and lead (Pb) are widespread environmental contaminants that are known nephrotoxins. However, their nephrotoxic effects at low-environmental exposure levels are debated.We examined the association of blood Pb (B-Pb), blood Cd (B-Cd), urinary Pb (U-Pb) and urinary Cd (U-Cd) with estimated glomerular filtration rate (eGFR) and urinary albumin (ALB).We used multivariate linear regression to analyze the association between B-Pb, B-Cd, U-Pb, and U-Cd with eGFR and ALB in adult participants (?20 years of age) in NHANES 2007-2012. The dataset was limited to NHANES individuals with both blood and urinary metal measurements.We found a statistically significant inverse association between eGFR and B-Cd and statistically significant positive associations between eGFR and both U-Cd and U-Pb, as well as statistically significant associations between ALB and the 3rd and 4th quartiles of U-Cd.The inverse association between eGFR and B-Cd, in conjunction with positive associations between eGFR and ALB with U-Cd, suggest that U-Cd measurement at low levels of exposure may result from changes in renal excretion of Cd due to kidney function and protein excretion. However, renal effects such as hyperfiltration from Cd-mediated kidney damage or creatinine-specific Cd effects cannot be excluded with this cross-sectional design.

SUBMITTER: Buser MC

PROVIDER: S-EPMC5685486 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012.

Buser Melanie C MC Ingber Susan Z SZ Raines Nathan N Fowler David A DA Scinicariello Franco F

International journal of hygiene and environmental health 20160128 3

<h4>Background</h4>Cadmium (Cd) and lead (Pb) are widespread environmental contaminants that are known nephrotoxins. However, their nephrotoxic effects at low-environmental exposure levels are debated.<h4>Objective</h4>We examined the association of blood Pb (B-Pb), blood Cd (B-Cd), urinary Pb (U-Pb) and urinary Cd (U-Cd) with estimated glomerular filtration rate (eGFR) and urinary albumin (ALB).<h4>Methods</h4>We used multivariate linear regression to analyze the association between B-Pb, B-Cd, ...[more]

PMID: 26852280

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Dataset Information

Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012.

Publications

Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012.

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