Dataset Information
Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.
Ontology highlight
ABSTRACT:
SUBMITTER: Ortiz GX
PROVIDER: S-EPMC5685508 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.
Organic letters 20170310 6
Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl<sub>2</sub>. Interestingly, analogous reactions in the absence of ZnCl<sub>2</sub> resulted in the formation of indole aminal products. ...[more]