Protective effect of metformin against retinal vein occlusions in diabetes mellitus - A nationwide population-based study.

ABSTRACT: Previous studies have found that metformin can reduce cardiovascular risk, but its association with retinal vein occlusion (RVO) is unknown. In this population-based cohort study using the Taiwan National Health Insurance Research Database (NHIRD), we demonstrated the protective effect of metformin against RVO in diabetes mellitus (DM) and explored the incidence rate and factors associated with RVO development in general and diabetic populations. One million patients were randomly selected from the registry files of the NHIRD, and all their claims data were collected for the 1996-2011 period. Patients with a new diagnosis of central or branch RVO were identified using International Classification of Disease codes. DM was defined for patients with diagnoses and treatments. Factors associate

SUBMITTER: Lin TC 

PROVIDER: S-EPMC5685597 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature