Serum and Extracellular Vesicle MicroRNAs miR-423, miR-199, and miR-93* As Biomarkers for Acute Graft-versus-Host Disease.
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ABSTRACT:
SUBMITTER: Crossland RE
PROVIDER: S-EPMC5686047 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Serum and Extracellular Vesicle MicroRNAs miR-423, miR-199, and miR-93* As Biomarkers for Acute Graft-versus-Host Disease.
Crossland Rachel E RE Norden Jean J Kralj Juric Mateja M Pearce Kim F KF Lendrem Clare C Bibby Louis A LA Collin Matthew M Greinix Hildegard T HT Dickinson Anne M AM
Frontiers in immunology 20171110
Acute graft-versus-host disease (aGvHD) is a major cause of adverse outcome in hematopoietic stem cell transplantation (HSCT), with a high incidence (20-50%). A novel, non-invasive diagnostic test to predict for prevalence and severity would enable improved prophylaxis and reduce morbidity. Circulatory microRNAs (miRNAs) miR-423, miR-199, miR-93*, and miR-377 have previously been associated with aGvHD in post-HSCT patient plasma, but validation is lacking and their expression within extracellula ...[more]
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