Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC5686148 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Ma Xiaoyu X Wang Lin L Huang De Li Yunyan Y Yang Dongdong D Li Tingting T Li Fudong F Sun Linchong L Wei Haoran H He Kun K Yu Fazhi F Zhao Debiao D Hu Lan L Xing Songge S Liu Zhaoji Z Li Kui K Guo Jing J Yang Zhenye Z Pan Xin X Li Ailing A Shi Yunyu Y Wang Junfeng J Gao Ping P Zhang Huafeng H
Nature communications 20171115 1
Two hallmarks for cancer cells are the accelerated cell cycle progression as well as the altered metabolism, however, how these changes are coordinated to optimize the growth advantage for cancer cells are still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator for cell mitosis, plays a critical role for biosynthesis in cancer cells through activating pentose phosphate pathway (PPP). We find that Plk1 interacts with and directly phosphorylates glucose-6-phosphat ...[more]