Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC5686148 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171115 1
Two hallmarks for cancer cells are the accelerated cell cycle progression as well as the altered metabolism, however, how these changes are coordinated to optimize the growth advantage for cancer cells are still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator for cell mitosis, plays a critical role for biosynthesis in cancer cells through activating pentose phosphate pathway (PPP). We find that Plk1 interacts with and directly phosphorylates glucose-6-phosphat ...[more]