Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC5686190 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhou Xuelin X Li Haotian H Shi Zhilong Z Gao Sijia S Wei Shizhang S Li Kun K Wang Jiabo J Li Jianyu J Wang Ruilin R Gong Man M Zhao Yanling Y Xiao Xiaohe X
Scientific reports 20171114 1
Huang-Lian-Jie-Du-Tang (HLJDT), a traditional formula with four TCM herbs, has been used for hundred years for different diseases. The current study aimed to assess the inhibitory activity of HLJDT against H1N1 neuraminidase (NA-1), and identify potent NA-1 inhibitors from its plasma profile. The in vitro NA-1 study has shown that the water extract of HLJDT potently inhibited NA-1 (IC<sub>50</sub> = 112.6 μg/ml; Ki = 55.6 μg/ml) in a competitive mode. The IC<sub>50</sub> values of the water extr ...[more]