Ontology highlight
ABSTRACT:
SUBMITTER: Carr SM
PROVIDER: S-EPMC5686351 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Carr Simon M SM Munro Shonagh S Sagum Cari A CA Fedorov Oleg O Bedford Mark T MT La Thangue Nicholas B NB
Cell death and differentiation 20170825 12
The retinoblastoma tumour suppressor protein (pRb) classically functions to regulate early cell cycle progression where it acts to enforce a number of checkpoints in response to cellular stress and DNA damage. Methylation at lysine (K) 810, which occurs within a critical CDK phosphorylation site and antagonises a CDK-dependent phosphorylation event at the neighbouring S807 residue, acts to hold pRb in the hypo-phosphorylated growth-suppressing state. This is mediated in part by the recruitment o ...[more]