Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC5686357 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhu Yahui Y Gu Li L Li Yajun Y Lin Xi X Shen Hongxing H Cui Kaisa K Chen Li L Zhou Feng F Zhao Qiu Q Zhang Jinxiang J Zhong Bo B Prochownik Edward E Li Youjun Y
Cell death and differentiation 20170929 12
miR-148a has been shown to regulate inflammation, immunity and the growth of certain tumors, but its roles in colitis and colorectal tumorigenesis remain largely undetermined. Here we found miR-148a-deficient mice to be more susceptible to colitis and colitis-associated tumorigenesis. Both were associated with increased nuclear factor κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) signaling. Bone marrow- and non-bone marrow-derived miR-148a contributed to colitis and c ...[more]