Imaging Microglial Activation in Individuals at Clinical High Risk for Psychosis: an In Vivo PET Study with [¹⁸F]FEPPA.

ABSTRACT: Several lines of evidence implicate microglial activation and abnormal immune response in the etiology of psychosis. Previous positron emission tomography (PET) neuroimaging studies of the translocator protein 18 kDa, TSPO, were limited by low affinity of the first-generation radioligand, low-resolution scanners, and small sample sizes. Moreover, there is a dearth of literature on microglial activation in individuals at clinical high risk (CHR) for psychosis. We used a novel second-generation TSPO radioligand, [¹⁸F]FEPPA, to examine whether microglial activation is elevated in the dorsolateral prefrontal cortex (DLPFC) and hippocampus of antipsychotic-naive CHR. Twenty-four CHR (antipsychotic-naive n=22) and 23 healthy volunteers (HV) completed a high resolution [¹⁸F]

SUBMITTER: Hafizi S 

PROVIDER: S-EPMC5686484 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature