Ontology highlight
ABSTRACT:
SUBMITTER: Cortes M
PROVIDER: S-EPMC5686549 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cortés Marlies M Sanchez-Moral Lidia L de Barrios Oriol O Fernández-Aceñero María J MJ Martínez-Campanario M C MC Esteve-Codina Anna A Darling Douglas S DS Győrffy Balázs B Lawrence Toby T Dean Douglas C DC Postigo Antonio A
The EMBO journal 20171016 22
Accumulation of tumor-associated macrophages (TAMs) associates with malignant progression in cancer. However, the mechanisms that drive the pro-tumor functions of TAMs are not fully understood. ZEB1 is best known for driving an epithelial-to-mesenchymal transition (EMT) in cancer cells to promote tumor progression. However, a role for ZEB1 in macrophages and TAMs has not been studied. Here we describe that TAMs require ZEB1 for their tumor-promoting and chemotherapy resistance functions in a mou ...[more]