Dataset Information

A novel approach to analyzing lung cancer mortality disparities: Using the exposome and a graph-theoretical toolchain.

ABSTRACT:

Objectives

The aim is to identify exposures associated with lung cancer mortality and mortality disparities by race and gender using an exposome database coupled to a graph theoretical toolchain.

Methods

Graph theoretical algorithms were employed to extract paracliques from correlation graphs using associations between 2162 environmental exposures and lung cancer mortality rates in 2067 counties, with clique doubling applied to compute an absolute threshold of significance. Factor analysis and multiple linear regressions then were used to analyze differences in exposures associated with lung cancer mortality and mortality disparities by race and gender.

Results

While cigarette consumption was highly correlated with rates of lung cancer mortality for both white men and women, previously unidentified novel exposures were more closely associated with lung cancer mortality and mortality disparities for blacks, particularly black women.

Conclusions

Exposures beyond smoking moderate lung cancer mortality and mortality disparities by race and gender.

Policy implications

An exposome approach and database coupled with scalable combinatorial analytics provides a powerful new approach for analyzing relationships between multiple environmental exposures, pathways and health outcomes. An assessment of multiple exposures is needed to appropriately translate research findings into environmental public health practice and policy.

SUBMITTER: Juarez PD

PROVIDER: S-EPMC5687093 | biostudies-literature | 2017 Apr-Jun

REPOSITORIES: biostudies-literature

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Publications

A novel approach to analyzing lung cancer mortality disparities: Using the exposome and a graph-theoretical toolchain.

Juarez Paul D PD Hood Darryl B DB Rogers Gary L GL Baktash Suzanne H SH Saxton Arnold M AM Matthews-Juarez Patricia P Im Wansoo W Cifuentes Myriam Patricia MP Phillips Charles A CA Lichtveld Maureen Y MY Langston Michael A MA

Environmental disease 20170401 2

<h4>Objectives</h4>The aim is to identify exposures associated with lung cancer mortality and mortality disparities by race and gender using an exposome database coupled to a graph theoretical toolchain.<h4>Methods</h4>Graph theoretical algorithms were employed to extract paracliques from correlation graphs using associations between 2162 environmental exposures and lung cancer mortality rates in 2067 counties, with clique doubling applied to compute an absolute threshold of significance. Factor ...[more]

PMID: 29152601

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Dataset Information

A novel approach to analyzing lung cancer mortality disparities: Using the exposome and a graph-theoretical toolchain.

Objectives

Methods

Results

Conclusions

Policy implications

Publications

A novel approach to analyzing lung cancer mortality disparities: Using the exposome and a graph-theoretical toolchain.

Similar Datasets

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