P300 Knockout Promotes Butyrate Resistance.
Ontology highlight
ABSTRACT:
SUBMITTER: Lazarova DL
PROVIDER: S-EPMC5687153 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
p300 Knockout Promotes Butyrate Resistance.
Lazarova Darina L DL Bordonaro Michael M
Journal of Cancer 20170920 17
Dietary fiber is linked to a reduced risk of colorectal cancer (CRC), and this protective activity is likely due to its fermentation product, butyrate. Dependent upon the hyperactivation of Wnt signaling, butyrate represses CRC cell growth and induces apoptosis. However, resistance to butyrate activity may allow for CRC development even in the context of relatively high fiber intake. We have previously determined that CRC cells resistant to butyrate are deficient in p300 expression. The histone ...[more]
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