Ontology highlight
ABSTRACT:
SUBMITTER: Kalan S
PROVIDER: S-EPMC5687273 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Kalan Sampada S Amat Ramon R Schachter Miriam Merzel MM Kwiatkowski Nicholas N Abraham Brian J BJ Liang Yanke Y Zhang Tinghu T Olson Calla M CM Larochelle Stéphane S Young Richard A RA Gray Nathanael S NS Fisher Robert P RP
Cell reports 20171001 2
Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies. However, whereas selective inhibition of analog-sensitive (AS) Cdk7 in colon cancer-derived cells arrests division and disrupts transcription, it does not by itself trigger apoptosis efficiently. Here, we show that p53 activation by 5-fluorouracil or nutlin-3 synergizes with a reversible Cdk7<sup>as</sup> inhibitor to ...[more]