Ontology highlight
ABSTRACT:
SUBMITTER: Valvezan AJ
PROVIDER: S-EPMC5687294 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Valvezan Alexander J AJ Turner Marc M Belaid Amine A Lam Hilaire C HC Miller Spencer K SK McNamara Molly C MC Baglini Christian C Housden Benjamin E BE Perrimon Norbert N Kwiatkowski David J DJ Asara John M JM Henske Elizabeth P EP Manning Brendan D BD
Cancer cell 20171019 5
The mechanistic target of rapamycin complex 1 (mTORC1) supports proliferation through parallel induction of key anabolic processes, including protein, lipid, and nucleotide synthesis. We hypothesized that these processes are coupled to maintain anabolic balance in cells with mTORC1 activation, a common event in human cancers. Loss of the tuberous sclerosis complex (TSC) tumor suppressors results in activation of mTORC1 and development of the tumor syndrome TSC. We find that pharmacological inhib ...[more]