Ontology highlight
ABSTRACT:
SUBMITTER: Murphy RE
PROVIDER: S-EPMC5687296 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Murphy R Elliot RE Samal Alexandra B AB Vlach Jiri J Saad Jamil S JS
Structure (London, England : 1993) 20171019 11
The cytoplasmic tail of gp41 (gp41CT) remains the last HIV-1 domain with an unknown structure. It plays important roles in HIV-1 replication such as mediating envelope (Env) intracellular trafficking and incorporation into assembling virions, mechanisms of which are poorly understood. Here, we present the solution structure of gp41CT in a micellar environment and characterize its interaction with the membrane. We show that the N-terminal 45 residues are unstructured and not associated with the m ...[more]