Ontology highlight
ABSTRACT:
SUBMITTER: Barnicle A
PROVIDER: S-EPMC5687324 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Barnicle Alan A Seoighe Cathal C Greally John M JM Golden Aaron A Egan Laurence J LJ
Epigenetics 20170530 8
Aberrant DNA methylation patterns have been reported in inflamed tissues and may play a role in disease. We studied DNA methylation and gene expression profiles of purified intestinal epithelial cells from ulcerative colitis patients, comparing inflamed and non-inflamed areas of the colon. We identified 577 differentially methylated sites (false discovery rate <0.2) mapping to 210 genes. From gene expression data from the same epithelial cells, we identified 62 differentially expressed genes wit ...[more]