Ontology highlight
ABSTRACT:
SUBMITTER: Robertson AG
PROVIDER: S-EPMC5687509 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cell 20171005 3
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival "neuronal" subtype in which the majority of tumors lacked sm ...[more]