Ontology highlight
ABSTRACT:
SUBMITTER: Stewart-Ornstein J
PROVIDER: S-EPMC5687840 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Stewart-Ornstein Jacob J Cheng Ho Wa Jacky HWJ Lahav Galit G
Cell systems 20171018 4
The tumor-suppressing transcription factor p53 is highly conserved at the protein level and plays a key role in the DNA damage response. One important aspect of p53 regulation is its dynamics in response to DNA damage, which include oscillations. Here, we observe that, while the qualitative oscillatory nature of p53 dynamics is conserved across cell lines derived from human, monkey, dog, mouse, and rat, the oscillation period is variable. Specifically, rodent cells exhibit rapid p53 oscillations ...[more]