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CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons.

ABSTRACT: Dendrite size and morphology are key determinants of the functional properties of neurons and neural circuits. Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendrite growth and elaboration in the developing brain. The dendrites of hippocampal excitatory neurons were markedly stunted in Cd40-/- mice, whereas those of striatal inhibitory neurons were much more exuberant. These striking and opposite phenotypic changes were also observed in excitatory and inhibitory neurons cultured from Cd40-/- mice and were rescued by soluble CD40. The changes in excitatory and inhibitory neurons cultured from Cd40-/- mice were mimicked in neurons of Cd40+/+ mice by treatment with soluble CD40L and were dependent on PKC-? and PKC-?, respectively. These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.

SUBMITTER: Carriba P

PROVIDER: S-EPMC5687868 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons.

Carriba Paulina P Davies Alun M AM

eLife 20171107

Dendrite size and morphology are key determinants of the functional properties of neurons and neural circuits. Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendrite growth and elaboration in the developing brain. The dendrites of hippocampal excitatory neurons were markedly stunted in <i>Cd40</i><sup>-/-</sup> mice, whereas those of striatal inhibitory neurons were much more exuberant. These striking and opposite phenotypic changes were also observed ...[more]

PMID: 29111976

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