Ontology highlight
ABSTRACT:
SUBMITTER: Qie S
PROVIDER: S-EPMC5688124 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Qie Shuo S Majumder Mrinmoyee M Mackiewicz Katarzyna K Howley Breege V BV Peterson Yuri K YK Howe Philip H PH Palanisamy Viswanathan V Diehl J Alan JA
Nature communications 20171116 1
The Fbxo4 tumour suppressor is a component of an Skp1-Cul1-F-box E3 ligase for which two substrates are known. Here we show purification of SCF<sup>Fbxo4</sup> complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as binding partners. Biochemical and functional analyses reveal that Fxr1 is a direct substrate of SCF<sup>Fbxo4</sup>. Consistent with a substrate relationship, Fxr1 is overexpressed in Fbxo4 knockout cells, tissues and in human cancer cells, harbou ...[more]