Ontology highlight
ABSTRACT:
SUBMITTER: Dahlin JL
PROVIDER: S-EPMC5688144 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Dahlin Jayme L JL Nelson Kathryn M KM Strasser Jessica M JM Barsyte-Lovejoy Dalia D Szewczyk Magdalena M MM Organ Shawna S Cuellar Matthew M Singh Gurpreet G Shrimp Jonathan H JH Nguyen Nghi N Meier Jordan L JL Arrowsmith Cheryl H CH Brown Peter J PJ Baell Jonathan B JB Walters Michael A MA
Nature communications 20171115 1
Many compounds with potentially reactive chemical motifs and poor physicochemical properties are published as selective modulators of biomolecules without sufficient validation and then propagated in the scientific literature as useful chemical probes. Several histone acetyltransferase (HAT) inhibitors with these liabilities are now routinely used to probe epigenetic pathways. We profile the most commonly used HAT inhibitors and confirm that the majority of them are nonselective interference com ...[more]