Ontology highlight
ABSTRACT:
SUBMITTER: Pudelko L
PROVIDER: S-EPMC5689565 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Pudelko Linda L Rouhi Pegah P Sanjiv Kumar K Gad Helge H Kalderén Christina C Höglund Andreas A Squatrito Massimo M Schuhmacher Alberto J AJ Edwards Steven S Hägerstrand Daniel D Berglund Ulrika Warpman UW Helleday Thomas T Bräutigam Lars L
Oncotarget 20170720 49
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with poor prognosis. Cancer cells are characterized by a specific redox environment that adjusts metabolism to its specific needs and allows the tumor to grow and metastasize. As a consequence, cancer cells and especially GBM cells suffer from elevated oxidative pressure which requires antioxidant-defense and other sanitation enzymes to be upregulated. MTH1, which degrades oxidized nucleotides, is one of these defense enzymes an ...[more]