Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC5689596 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Liu Huifang H Kong Xiangxin X Chen Fengling F
Oncotarget 20170718 49
Central precocious puberty (CPP) is attributed to the disorder of some trigger factors those can activate the hypothalamic-pituitary-gonadal axis controlled by GnRH neurons. Many recent studies reveal one of those trigger factors, Makorin ring finger protein 3 (Mkrn3), whose loss-of-function mutations are implicated in CPP. Although Mkrn3 contained zinc Ring finger domain is considered as a putative E3 ubiquitin ligase, its actual function is never reported. Here, our results demonstrated that i ...[more]