Ontology highlight
ABSTRACT:
SUBMITTER: Bai H
PROVIDER: S-EPMC5689617 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bai Hua H Wu Shuang S Wang Rong R Xu Ji J Chen Lijuan L
Oncotarget 20170803 49
Interferon regulator factor 4 (IRF4) is characterized to be a member of interferon regulatory family, which is predominantly expressed in bone marrow plasma cells of patients with multiple myeloma (MM). Recent studies indicated IRF4 is critical for T-help cells (Th17) differentiation and interleukin-17 (IL-17) secretion. Here, a total of 58 MM patients were enrolled in this study, the proportions of Th17 cells and T regulatory (Treg) cells in peripheral blood mononuclear cells (PBMCs) were deter ...[more]