Ontology highlight
ABSTRACT:
SUBMITTER: Sula Karreci E
PROVIDER: S-EPMC5690280 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Sula Karreci Esilida E Eskandari Siawosh K SK Dotiwala Farokh F Routray Sujit K SK Kurdi Ahmed T AT Assaker Jean Pierre JP Luckyanchykov Pavlo P Mihali Albana B AB Maarouf Omar O Borges Thiago J TJ Alkhudhayri Abdullah A Patel Kruti R KR Radwan Amr A Ghobrial Irene I McGrath Martina M Chandraker Anil A Riella Leonardo V LV Elyaman Wassim W Abdi Reza R Lieberman Judy J Azzi Jamil J
JCI insight 20171102 21
Tregs hold great promise as a cellular therapy for multiple immunologically mediated diseases, given their ability to control immune responses. The success of such strategies depends on the expansion of healthy, suppressive Tregs ex vivo and in vivo following the transfer. In clinical studies, levels of transferred Tregs decline sharply in the blood within a few days of the transfer. Tregs have a high rate of apoptosis. Here, we describe a new mechanism of Treg self-inflicted damage. We show tha ...[more]