Designing Safer Analgesics via ?-Opioid Receptor Pathways.
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ABSTRACT:
SUBMITTER: Chan HCS
PROVIDER: S-EPMC5690544 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Designing Safer Analgesics via μ-Opioid Receptor Pathways.
Chan H C Stephen HCS McCarthy Dillon D Li Jianing J Palczewski Krzysztof K Yuan Shuguang S
Trends in pharmacological sciences 20170919 11
Pain is both a major clinical and economic problem, affecting more people than diabetes, heart disease, and cancer combined. While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especially those acting on the μ-opioid receptor (μOR) and related pathways, have proven to be the most effective, despite some serious side effects including respiration depression, pruritus, dependence, and constipation. It is therefore imperative th ...[more]
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